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Immediately after 8 weeks of drug administration, the experimental rats were fasted overnight, the following morning, rats were anesthetized and blood was sampled Docetaxel in the abdominal aorta.



From the stack of cross section images, a volume of interest containing only cancellous NSCLC bone was extracted for morphometric analysis. The VOI started at a distance of 1 mm from the lower end of the growth plate and extended distally for 110 cross sections. For morphometric analysis, the following structural parameters were calculated over each VOI of cancellous bone by 3D analysis : bone volume fraction, connectivity density, trabecular thickness, direct trabecular separation, trabecular number, trabecular pattern factor, BMD, and structure model index. SMI indicates whether the trabeculae are more rod like or more plate like, Lower Tb. Pf signifies better connected trabecular lattices while higher Tb. Pf means a more disconnected trabecular structure, Conn.

With this protocol, the gray levels of voxels near the trabecular surfaces are not included to ensure that the measurements are not affected by partial volume effects. All DEXA measurements were Docetaxel performed by the same investigator using the Norland pDEXA Sabre equipped with Sabre Research software. The interassay coefficient of variation for BMD and BMC was 1. 7%. The scanner was calibrated daily to a dual material standard according to the manufacturers recommendations, and the scanner performance was controlled by the quality assurance protocol of our laboratory. The right femurs were scanned using DEXA to determine BMC and BMD.

The baseline point was located on the cotton piece. Liver specimens were fixed in 10% buffered neutral paraformaldehyde solution, processed and embedded in paraffin. Thin paraffin sections were stained by hematoxylin and eosin.