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We employed the human TNFalpha transgenic mouse to analyse the expression and function of syndecan AG-1478 4 in chronic destructive arthritis and reply the question whether inhibition of syndecan 4 by precise antibodies may possibly stop cartilagedestruction and/or boost the phenotype following onset in the disease in this animal model of human RA.

Evaluation of disease severity included clinical parameters too AG-1478 as histomorphometric analysis of toluidin blue stained paraffin sections. Results: As seen in immunohistochemistry, there was a strong expression of syndecan 4 in the synovial membranes of hTNFtg mice, whereas only negligible staining for syndecan 4 was found in synovial tissues of wild type animals. In vitro, synovial fibroblasts isolated from hTNFtg mice showed more than 30 fold higher expression of syndecan 4 than wild type controls. Administration of the anti syndecan 4 antibodies but not of IgG control in preventive treated 4 week old hTNFtg mice clearly ameliorated the clinical signs of arthritis and protected the treated joints from cartilage damage.

More importantly, the data suggest that inhibition VEGF of syndecan 4 not only prevens cartilage damage, but also reduces the severity after onset of the disease. Subject of the inquiry: 35 patients with rheumatoid arthritis, 50 mature male rats of mixed population. Aim of the inquiry: Clinical experimental assessment of simvastatin efficiency and pathogenic justification of its inclusion into the complex treatment for therapy optimization in patients with rheumatoid arthritis. Methods of investigation: clinical laboratory, biochemical determination of total cholesterol, low and high density lipoproteins, triglycerides, calculation of atherogenic coefficient in blood serum of patients with rheumatoid arthritis and in experimental animals.

It was suggested that one should include assessment of blood and joint fluid for nitrogen oxide, nitrate diaphorase and nitrate reductase in the algorithm of investigation and dynamic observation, choice of tactics and therapy AG-1478 efficiency assessment. Practical value: Obtained new data are necessary for increasing the pharmacotherapy efficacy in patients with rheumatoid arthritis taking into account the metabolic activity of NO synthetase mechanism in blood and synovial fluid. An algorithm was suggested for screening observation and differentiated management of patients with rheumatoid arthritis taking account of severity of nitrogen oxide metabolism disorders. A differentiated approach was worked out and justified of simvastatin prescription both to increase the efficacy of treatment taking into account the clinical activity of the disease and to correct metabolic disorders in patients with rheumatoid arthritis.

Increased AG-1478 prevalence of metabolic syndromein rheumatoid arthritis has been reported from American and European populations but it has not been studied in Indian patients with RA. Objectives: The main objective of our study was to assess the prevalence of the metabolic syndrome in Asian Indian patients with rheumatoid arthritis and also to studyits correlation with disease activity. Methods: This was a prospective case control study in which 114 patients diagnosed to have rheumatoid arthritis of more than 1 year duration and 114 healthy age and sex matched controls were included. Height, weight, body mass index, blood pressure and waist circumference of the patients were measured at the enrolment visit.

Metabolic syndrome was present in 36 patients and 17 controls according to the Adult Treatment Panel III criteria and in 40 patients and 18 controls according to the consensus definition of the metabolic syndrome for adult Asian patients.